Everson, D., and D. Weix. Cross-Electrophile Coupling: Principles of Reactivity and Selectivity. J. Org. Chem., 4798.
|Abstract||A critical overview of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity. Recent synthetic advances and mechanistic studies have shed light on four possible methods for overcoming this challenge: (1) employing an excess of one reagent; (2) electronic differentiation of starting materials; (3) catalyst-substrate steric matching; and (4) radical chain processes. Each method is described using examples from the recent literature.|
|Keywords||allylic acetates, aryl halides, bond-dissociation energies, c-c, catalyzed reductive allylation, nickel-complexes, organic halides, transition-metals, unactivated alkyl-halides, unsymmetrical biaryls|