Substituted 2,2 ‘-Bipyridines by Nickel Catalysis: 4,4 ‘-Di-tert-butyl-2,2 ‘-bipyridine

Buonomo, J., D. Everson, and D. Weix. Substituted 2,2 ‘-Bipyridines by Nickel Catalysis: 4,4 ‘-Di-Tert-Butyl-2,2 ‘-Bipyridine. Synthesis, 3102.
Abstract A simple, ligand-free synthesis of the important bipyridyl ligand 4,4-di-tert-butyl-2,2-bipyridine is presented. 5,5-Bis(trifluoromethyl)-2,2-bipyridine is also synthesized by the same protocol. The syntheses efficiently couple the parent 2-chloropyridines by a nickel-catalyzed dimerization with manganese powder as the terminal reductant.
Keywords 2-bipyridine44-di-tert-butyl-2acidalkyl-halidesaromatic halidesaryl halidesbromidesc-h activationcatalysiscomplexesderivativesnickelpalladiumpyridinereductiveunactivated alkyl
DOI 10.1055/s-0033-1338520